The laboratory researches of autoclave oxidation with follow cyanidation of sulphide gold-bearing ores and concentrates, contained organic carbonic substance from the one of deposit of the Amur region have been realized. The results of research for determination of optimal conditions of autoclave oxidation of ore and flotation concentrates, obtained via different beneficiation technologies have been presented. The influence of carbonic substance content in processing product on extraction of precious metals during cyanidation process has been educed. The results of researches have been shown, that gold and silver extraction during cyanidation depends on oxidation degree of pyrite in autoclave process. Autoclave opening allows to raise gold extraction from 6–15 till 86–90%. Gold extraction during cyanidation of products of autoclave oxidation essentially depends on mass correlation of gold and organic carbon.